Refining genetic stratification in T-ALL

Refining prognosis in BCR-ABL1-positive ALL.

T reatment of children with BCR-ABL1– positive ALL has been revolutionized with the advent of TKI therapy. Historically, children with BCR-ABL1–positive ALL were treated with intensive chemotherapy followed by allogeneic hematopoietic stem cell transplantation (HSCT), and despite this, event-free survival rates of ,50% were observed.With the advent of TKI therapy, outcomes have improved signifi...

Refining genetic associations in multiple sclerosis

Genome-wide association studies involve several hundred thousand markers and, even when quality control is scrupulous, are invariably confounded by residual uncorrected errors that can falsely infl ate the apparent diff erence between cases and controls (socalled genomic infl ation). As a consequence such studies inevitably generate false positives alongside genuine associations. By use of Baye...

Editorial: Refining Prevention: Genetic and Epigenetic Contributions

The current series of articles was designed to capture ongoing translational activities linking genetic and epigenetic research to enhancement of prevention and treatment efforts. Better understanding the processes associated with better and worse response to a range of environmental causes and to preventive interventions is a critical first step in refining and adapting existing prevention pro...

"R" for "renal" and for "risk": refining risk stratification for stroke in atrial fibrillation.

Calcineurin/CXCR4 in T-ALL

The calcineurin/NFAT signaling pathway is implicated in a wide variety of biological processes, acting as a bridge pathway between calcium signals and gene expression. Although its role as an effector of immune responses figured prominently in early studies, it forms just one part of a larger picture. Indeed calcineurin has been shown to participate in the development and function of e.g. the i...